February 10, 2009 - Four hospitals in western New York state used emergency treatment strategies emphasizing evidence-based therapy and better communication among healthcare providers to reduce heart attack patient deaths by 19 percent for up to one year after patient discharge.
The prospective research study, "Acute Coronary Syndrome Emergency Treatment Strategies: Improved Treatment and Reduced Mortality in Patients with Acute Coronary Syndrome Using Guideline-based Critical Care Pathways," (ACSETS) was published in January in the American Heart Journal. It is reportedly the first study to investigate an acute coronary syndrome critical care pathway approach in a population of patients encompassing the total acute coronary syndrome management spectrum.
"Previous work has established that hospitals adhering to certain performance measures in treating patients with heart attack had lower mortality," study lead author and practicing cardiologist John Corbelli, M.D., associate clinical professor of medicine for the State University of New York at Buffalo School of Medicine and Biomedical Sciences.. "We wanted to know if we could improve the mortality rates of these patients by developing a new approach -- or a new critical pathway -- to better assist medical staff in putting these published guidelines into practice."
"ACSETS was derived from the synergy between the cardiologists and emergency department physicians," said Dave Janicke, M.D., study co-author and clinical associate professor of emergency medicine at State University of New York at Buffalo School of Medicine and Biomedical Sciences. "The ACSETS guideline-driving pathway is initiated as soon as the ACS patient arrives in the Emergency Department and is subsequently carried through hospitalization including discharge medications and follow-up."
ACSETS, based on guidelines established by the American College of Cardiology and the American Heart Association, uses pre-printed order sheets customized for use in the emergency department, inpatient and discharge that simply the task of matching intensity of therapy to risk. Rather than follow the normal procedure of creating a new order sheet at every patient stop -- from the ER to the floor and then to discharge -- the same set of orders stayed with the patients as they made their journeys through the hospital.
Physicians and other medical staff members were trained on the ACSETS order sheets for a period over 26 weeks before the study began. ACSETS educates medical staff members throughout the continuum of patient care regarding key elements of the guidelines and encourages ready adherence to those guidelines at the bedside in a time-efficient manner.
Within the first 24 hours after arrival in the emergency department, at discharge and during 12 months following discharge, more ACSETS patients than pre-ACSETS patients received all eight guideline-based acute coronary syndrome treatment medications studied.
At discharge, ACSETS patients had their medications reviewed so that the appropriate drug therapies were prescribed. Patients were educated to understand the impact of their medications and the importance of compliance with the prescribed regimen. Study authors also met with local managed care groups to ensure that the design of their health plans allowed ACSETS patients easy access to cardiac therapies.
While the study showed no difference in in-patient mortality rates among the two groups, it did show that the ACSETS patients admitted for heart attack had a mortality rate of 19 percent less than the control group for up to one year after discharge.
"After discharge, higher refill rates were seen for the ACSETS group than for the pre-ACSETS group, with that difference showing statistical significance for clopidogrel and statins," Mark Cziraky, study co-author and HealthCore vice president of research development and operations said. HealthCore Inc., performed the outcomes research for the study based on research funding from Sanofi-Aventis, Bristol-Myers Squibb and the Kaleida Health Foundation.
ACSETS is used for the treatment of acute coronary syndrome patients with unstable angina, non-ST-segment elevation myocardial infarction (NSTEMI), or ST-elevation myocardial infarction (STEMI). The study group included 1,709 ACSETS patients and 1,240 pre-ACSETS control patients.
The study compares acute coronary syndrome care pre (Jan. 2, 2002) and post (May 1, 2003 to Aug. 31, 2004) in a four-hospital system in western New York state. Two hospitals were urban with cardiac catherization facilities and two other hospitals were suburban and lacked cardiac catherization facilities.
All patients were admitted to the hospital through the emergency department and discharged with a diagnosis of unstable angina, NSTEMI or STEMI. The intervention group consisted of patients with at least one ACSETS order sheet in their medical chart.
For more information: www.healthcore.com.
November 18, 2024 
