Cardiovascular Clinical Studies

This channel includes news and new technology innovations from cardiovascular clinical trials. These clinical studies include all cardiac subspecialties.

The mechanism of action for mavacamten, a cardiac myosin inhibitor to treat obstructive hypertrophic cardiomyopathy (oHCM). EXPLORER-HCM trial #ACC21 #ACC2021

News | Pharmaceuticals

Mavacamten Is Effective in Treating Obstructive Hypertrophic Cardiomyopathy

May 15, 2021 — A new analysis of the Phase 3 EXPLORER-HCM study evaluating mavacamten, an investigational, first-in ...

May 15, 2021

The combination heart failure drug sacubitril/valsartan did not significantly reduce the rate of heart failure or cardiovascular death following a heart attack compared to ramipril, an angiotensin converting enzyme (ACE) inhibitor. #ACC21 #ACC2021

News | Heart Failure

Sacubitril/Valsartan Does Not Outperform ACE Inhibitor in Preventing Heart Failure After Heart Attack

May 15, 2021 — The combination heart failure drug sacubitril/valsartan (Entresto) did not significantly reduce the rate ...

May 15, 2021

In the LAAOS III trial, surgeons could seal off the LAA during the open heart procedure using sutures, staples or approved closure devices. The image shows a SentraHeart lasso type LAA occluder about to seal off the LAA from the outside of the heart. #ACC21 #ACC2021

News | Left Atrial Appendage (LAA) Occluders

Left Atrial Appendage Occlusion Reduces Stroke After Heart Surgery

May 15, 2021 — Patients with an elevated risk of stroke due to heart rhythm problems, or atrial fibrillation (AFib) ...

May 15, 2021

An Edward Lifesciences Sapien TAVR valve during an implant procedure on angiography. There are still questions on how to best anticoagulate TAVR patients and the ATLANTIS study found Eloquis is not a good solution.

News | Structural Heart

TAVR Anticoagulation With Apixaban Not Superior to Standard Care

May 15, 2021 — The anticoagulant apixaban (Eliquis) was not superior to standard of care following transcatheter aortic ...

May 15, 2021

Explaining the Emory TMVR angle. Discordance between mitral annular centerline (yellow lines) and valve orientation imposed by guidewire position within the LV apex (red dashed lines). (B) Valve intrinsic angle (α) is determined by external skirt height. (C) When annular-apical “Emory” angle (red curves) exceeds α (blue curve), annular skirt apposition is not possible, causing PVL (red arrows). (D) The valve is oriented perpendicular to the annual plane using an exteriorized apical guidewire.

Feature | Structural Heart | By Dave Fornell, Editor

The Emory Angle Can Help Eliminate Paravalvular Leak in Transcatheter Mitral Interventions

The mitral valve anatomy is extremely complex, which has caused many challenges for transcatheter mitral valve ...

May 13, 2021

Videos | Structural Heart

VIDEO: Harmony Transcatheter Pulmonary Valve Has Good Outcomes at 1 Year

Tom Jones, M.D., director, cardiac catheterization laboratories, Seattle Children’s Hospital, and principle investigator ...

May 13, 2021

The BioCardia cardiac stem cell CardiAMP trial is a Phase III study looking at the efficacy of using stem cells to improve heart function in heart failure patients. It is the first trial for this technology to reach Phase III trial.

Feature | Stem Cell Therapies | By Simon H. Stertzer, M.D.

Is Cardiac Cell Therapy Worth Another Look?

Heart failure remains an unheralded global pandemic, costing society billions of dollars each year.[1,2] Projections ...

May 11, 2021

The Eko digital stethoscope can record heart soubnds and use an artificial intelligence (AI) analysis algorithm to detect heart murmurs. I new study in the JAHA showed it has comparable performance to that of an expert cardiologist. Eko Digital Stethoscope AI Analysis Algorithm Validated in JAHA article for Detecting Heart Murmurs

News | Artificial Intelligence

Eko Digital Stethoscope AI Analysis Algorithm Validated for Detecting Heart Murmurs

May 10, 2021 — Eko announced the peer-reviewed publication of a clinical study that found that the Eko artificial ...

May 10, 2021

Videos | Radial Access

VIDEO: Radial Hemostasis Reduced by 50 Percent With StatSeal in Combination With TR Band

Arnold Seto, M.D., MPA, FSCAI, chief of cardiology, Long Beach Veterans Affairs Medical Center and director ...

May 06, 2021

Videos | Coronavirus (COVID-19)

VIDEO: The Impact of COVID-19 on Heart Attack Patients

Payam Dehghani, M.D., FRCPC, FACC, FSCAI, co-director of Prairie Vascular Research and associate professor at the ...

May 06, 2021

SCAI 2021 late-breaking presentations included the data on the Medtronic Harmony transcatheter pulmonary valve, cutting radial access hemostasis time by 50 percent, improving cardiogenic shock survival to 71 percent, and data showing very high mortality in COVID patients who suffer a STEMI heart attack. #SCAI21 #SCAI2021

Feature | Cath Lab | By Dave Fornell, Editor

SCAI 2021 Late-breaking Clinical Study Results

April 29, 2021 — Here is the list of late-breaking study presentations and links to articles about each of them from the ...

May 06, 2021

The Bluegrass Vascular Surfacer System is designed to reliably, efficiently and repeatedly gain central venous access by inserting the Surfacer System through the right femoral vein and navigating it up through the patient’s venous system with an exit point in the right internal jugular vein, the optimal location for placing a central venous catheter.

News | EP Lab

Case Report on CRT Lead Placement in Obstructed Veins Using Surfacer System

May 6, 2021 - Bluegrass Vascular Technologies announced the publication of a report documenting the clinical utility of ...

May 06, 2021

Videos | Cath Lab

VIDEO: Avoiding Higher Risk Cath Lab Patients May Not Improve Outcomes Scores

Ashwin Nathan M.D., a cardiology fellow in the division of Cardiovascular Medicine at the Hospital of the University of ...

May 05, 2021

The Corindus CorPath robotic cath lab navigation system allows operators to sit and control the procedure from behind a lead-lined booth, so they do not have to wear heavy aprons during the procedures. Christoper Baker, M.D., Hoag Memorial Hospital using the system. #SCAI21 #SCAI2021

Feature | Robotic Systems

Second Generation Robotic PCI System Performs Well Across Spectrum of Lesion Complexity

May 5, 2021 — A late-breaking study of the Siemens Healthineers Corindus Corpath GRX second-generation cath lab robotic ...

May 05, 2021

Avoiding high-risk PCI procedures does not improve hospital scores according to a study presented at SCAI 2021. CTO procedure at Henry Ford Hospital, Detroit. Photo by Dave Fornell.

News | Cardiovascular Business

Avoiding High-risk Cath Lab Procedures Does Not Necessarily Improve Hospital Scores

May 5, 2021 — A late-breaking study presented at the Society for Cardiovascular Angiography and Interventions (SCAI) 202 ...

May 05, 2021