TCT23 Late-breakers: Full Schedule Announced

Late-breaking trials will be presented during the main sessions and highlighted during press conferences scheduled for Oct. 24, 25 and 26

Innovation. Connection. Inspiration. The Transcatheter Cardiovascular Therapeutics (TCT) 2023 conference, the Cardiovascular Research Foundation’s (CRF) annual scientific symposium and one of the most foremost educational forums specializing in interventional cardiovascular medicine, will offer it all. TCT, which will be held October 23-26, 2023, in San Francisco at the Moscone Center, will be celebrating 35 years of leading the field.

For more than three decades, TCT has ignited innovation, education, and connection in interventional cardiology, with the purpose of improving the survival and quality of life of patients suffering from heart and vascular disease. Every year, TCT features cutting-edge research in interventional cardiovascular medicine that directly impacts patient care and how physicians treat heart disease.

In the fast-paced world of medical advancements, late-breaking trials are highly anticipated and offer clinicians the opportunity to learn about new interventions, drugs, techniques, or strategies that could potentially improve patient outcomes. The 12 studies selected for presentation at TCT examine the safety and effectiveness of minimally invasive techniques, pharmaceuticals, technologies, and devices that demonstrate potential to treat or prevent cardiovascular disease.

Late-breaking trials will be presented during the main sessions and highlighted during press conferences scheduled for Tuesday, October 24, Wednesday, October 25, and Thursday, October 26. The complete list of late-breakers is as follows.

Late-breaking Clinical Trials: Session I, in collaboration with the New England Journal of Medicine

Tuesday, October 24, 11:00 AM — 12:28 PM PDT

Room: Innovation & Clinical Science Theater, Hall B, Exhibition Level, Moscone South, Moscone Center

This content is not CME/MOC accredited

Moderators

Jane A. Leopold, Patrick T. O'Gara

Discussants

David H. Adams, Robert O. Bonow, Megan Coylewright, Victoria Delgado, Stephan Windecker, Steven J. Yakubov

11:00 am: Five-Year Clinical and Echocardiographic Outcomes From The PARTNER 3 Low-Risk Randomized Trial

Late-Breaking Trial Presenter: Martin B. Leon

11:12 am: Discussion

Lead Discussant: Stephan Windecker

11:22 am: Four-Year Outcomes From the EVOLUT Low Risk Trial

Late-Breaking Trial Presenter: Michael J. Reardon

11:34 am: Discussion

Lead Discussant: Victoria Delgado

11:44 am: Safety and Efficacy of Left Atrial Appendage Occlusion at the Time of Transcatheter Aortic Valve Replacement - WATCH TAVR Trial Results

Late-Breaking Trial Presenter: Samir R. Kapadia

11:56 am: Discussion

Lead Discussant: Megan Coylewright

12:06 pm: ALIGN-AR Trial: Initial Outcomes of the JenaValve Trilogy Transcatheter Aortic Valve Replacement in High Risk Patients With Symptomatic Severe Native Aortic Regurgitation

Late-Breaking Trial Presenter: Vinod H. Thourani

12:18 pm: Discussion

Lead Discussant: Robert O. Bonow

Late-breaking Clinical Science: Session I, in collaboration with the Journal of the American College of Cardiology

Tuesday, October 24, 2- 3:30 pm PDT

Room: Innovation & Clinical Science Theater, Hall B, Exhibition Level, Moscone South, Moscone Center

This content is not CME/MOC accredited

Moderators

David J. Cohen, David J. Moliterno

Discussants

Gorav Ailawadi, Joanna Chikwe, Linda D. Gillam, Philipp Lurz, Vivek Y. Reddy, Brian K. Whisenant

2 pm: Five-year Echocardiographic Outcomes From The PARTNER 3 Low-risk Randomized Trial

Late-Breaking Science Presenter: Rebecca T. Hahn

2:10 pm: Discussion

Lead Discussant: Linda D. Gillam

2:18 pm: Tendyne SUMMIT Pivotal Trial Roll-In and MAC Arm Outcomes

Late-Breaking Science Presenters: Jason H. Rogers, Vinod H. Thourani

2:28 pm: Discussion

Lead Discussant: Joanna Chikwe

2:36 pm: TRILUMINATE Pivotal: Outcomes of Both Randomized and Single-arm Subjects with Transcatheter Tricuspid Valve Edge-to-Edge Repair for Tricuspid Regurgitation

Late-Breaking Science Presenter: David H. Adams

2:46 pm: Discussion

Lead Discussant: Gorav Ailawadi

2:54 pm: One-Year Outcomes after Amulet or Watchman/FLX Device for Percutaneous Left Atrial Appendage Closure: a Pre-Specified Analysis of the SWISS-APERO Randomized Clinical Trial

Late-Breaking Science Presenter: Roberto Galea

3:04 pm: Discussion

Lead Discussant: Vivek Y. Reddy

3:12 pm: One-Year Outcomes with Fourth-Generation Mitral Valve Transcatheter Edge-to-Edge Repair from EXPAND G4

Late-Breaking Science Presenter: Ralph Stephan von Bardeleben

3:22 pm: Discussant

Lead Discussant: Brian K. Whisenant

Late-breaking Clinical Trials: Session II, in collaboration with The Lancet

Wednesday, October 25, 11 am — 12:28 pm PDT

Room: Innovation & Clinical Science Theater, Hall B, Exhibition Level, Moscone South, Moscone Center

This content is not CME/MOC accredited

Moderators

Roxana Mehran, Stuart Spencer

Discussants

Dominick J. Angiolillo, Roisin Colleran, David E. Kandzari, Adnan Kastrati, Jennifer Rymer, Marco Valgimigli

11:00 am: Primary Outcomes of the Esprit BTK Drug-Eluting Resorbable Scaffold for the Treatment of Infrapopliteal Lesions: The LIFE-BTK Randomized Controlled Trial

Late-Breaking Trial Presenter: Ramon L. Varcoe

11:12 am: Discussion

Lead Discussant: David E. Kandzari

11:22 am: Primary Outcomes of a Pivotal Multicenter Randomized Trial Comparing the AGENT Paclitaxel-Coated Balloon With Conventional Balloon Angioplasty for In-Stent Restenosis

Late-Breaking Trial Presenter: Robert W. Yeh

11:34 am: Discussion

Lead Discussant: Roisin Colleran

11:44 am: Less Than 1-Month Dual Antiplatelet Therapy Followed by Ticagrelor Monotherapy After Coronary Drug-Eluting Stent Implantation for Acute Coronary Syndrome: A Randomized Trial

Late-Breaking Trial Presenter: Myeong-Ki Hong

11:56 am: Discussion

Lead Discussant: Marco Valgimigli

12:06 pm: Pressure-Controlled Intermittent Coronary Sinus Occlusion (PiCSO) in Acute Myocardial Infarction: The Randomized PICSO-AMI-I Trial

Late-Breaking Trial Presenter: Giovanni Luigi De Maria

12:18 pm: Discussion

Lead Discussant: Adnan Kastrati

Late-breaking Clinical Science: Session II, in collaboration with Circulation

Wednesday, October 25, 2- 3:30 pm PDT

Room: Innovation & Clinical Science Theater, Hall B, Exhibition Level, Moscone South, Moscone Center

This content is not CME/MOC accredited

Moderators

Joseph A. Hill, Ajay J. Kirtane

Discussants

Fernando Alfonso, Robert A. Byrne, Akiko Maehara, Margaret B. McEntegart, Duk-Woo Park, Bruno Scheller

2:00 pm: Sirolimus-Coated Balloon Versus Paclitaxel-Coated Balloon for the Treatment of Drug-Eluting Stent In-Stent Restenosis: A Prospective, Multicenter, Randomized Trial

Late-Breaking Science Presenter: ShaoLiang Chen

2:10 pm: Discussion

Lead Discussant: Bruno Scheller

2:18 pm: The Primary Endpoint Results from the COMPARE 60/80 HBR Trial: A Randomized Controlled Multi-Center Trial Comparing Ultrathin With Thin Strut Stents in High Bleeding Risk Patients With an Abbreviated DAPT Duration

Late-Breaking Science Presenter: Pieter C. Smits

2:28 pm: Discussion

Lead Discussant: Duk-Woo Park

2:36 pm: Polymer-Free Amphilimus-Eluting Stents vs. Biodegradable-Polymer Everolimus-Eluting Stents in All-Comers Undergoing PCI: 1-Year Results of the PARTHENOPE Trial

Late-Breaking Science Presenter: Giovanni Esposito

2:46 pm: Discussion

Lead Discussant: Robert A. Byrne

2:54 pm: Long-Term Outcomes with Biodegradable Polymer Sirolimus-Eluting Stents Versus Durable Polymer Everolimus-Eluting Stents in Patients With ST-Segment Elevation Myocardial Infarction: 5-Year Follow-up of the Biostemi Randomized Trial

Late-Breaking Science Presenter: Juan F. Iglesias

3:04 pm: Discussion

Lead Discussant: Margaret B. McEntegart

3:12 pm: Long-term Clinical Outcomes After iFR vs. FFR Guided Coronary Revascularization – Insights From the SWEDEHEART National Registry

Late-Breaking Science Presenter: Matthias Götberg

3:22 pm: Discussion

Lead Discussant: Akiko Maehara

Late-breaking Clinical Trials: Session III, in collaboration with the Journal of the American Medical Association

Thursday, October 26, 11 am — 12:30 pm PDT

Room: Innovation & Clinical Science Theater, Hall B, Exhibition Level, Moscone South, Moscone Center

This content is not CME/MOC accredited

Moderators

Robert O. Bonow, Juan F. Granada

Discussants

Saif Anwaruddin, Anita W. Asgar, Suzanne J. Baron, Scott M. Chadderdon, Nimesh Desai, David Hildick-Smith, Tsuyoshi Kaneko

11:00 am: TRISCEND II: A Randomized Trial of Transcatheter Tricuspid Valve Replacement in Patients with Severe Tricuspid Regurgitation

Late-Breaking Trial Presenter: Susheel K. Kodali

11:12 am: Discussion

Lead Discussant: Nimesh Desai

11:22 am: Quality of Life After Transcatheter Tricuspid-Valve Repair vs. Medical Therapy in Patients with Severe Tricuspid Regurgitation: Results From the Randomized TRILUMINATE Pivotal Trial

Late-Breaking Trial Presenter: Suzanne V. Arnold

11:34 am: Discussion

Lead Discussant: Suzanne J. Baron

11:44 am: Trancatheter Versus Surgical Aortic Valve Replacement in Patients With Severe Aortic Stenosis and Small Aortic Annuli: A Randomized Clinical Trial (the VIVA Trial)

Late-Breaking Trial Presenter: Josep Rodés-Cabau

11:56 am: Discussion

Lead Discussant: Saif Anwaruddin

12:06 pm: Clasp IID Updates and Complex Anatomy Registry

Late-Breaking Trial Presenters: Robert L. Smith, Firas Zahr

12:20 pm: Discussion

Lead Discussant: Anita W. Asgar

Late-Breaking Clinical Science: Session III, in Collaboration with the European Heart Journal/EuroIntervention

Thursday, October 26, 2-3:30 pm PDT

Room: Innovation & Clinical Science Theater, Hall B, Exhibition Level, Moscone South, Moscone Center

This content is not CME/MOC accredited

Moderators

Davide Capodanno, George D. Dangas

Discussants

Alexandre Abizaid, Mirvat Alasnag, Debbie Cohen, Marie-Claude Morice, Tamim M. Nazif, Amit N. Vora

2:00 pm: Individual Patient-data Pooled Analysis of Endovascular Ultrasound Renal Denervation or a Sham Procedure at 6 Months in the RADIANCE Clinical Trial Program

Late-Breaking Science Presenter: Ajay J. Kirtane

2:10 pm: Discussion

Lead Discussant: Debbie Cohen

2:18 pm: Recurrent Revascularization After Treatment Of Drug-Eluting Stent Restenosis With Drug-Coated Balloon, Plain Balloon Or Drug-Eluting Stent 10-Year Results From the Randomized ISAR-DESIRE 3 Trial

Late-Breaking Science Presenter: Tobias Koch

2:28 pm: Discussion

Lead Discussant: Mirvat Alasnag

2:36 pm: Drug-Coated Balloon for Acute Coronary Syndromes: A Multicenter Randomized Non-inferiority Trial (DCB-ACS Trial)

Late-Breaking Science Presenter: Haibo Jia

2:46 pm: Discussion

Lead Discussant: Alexandre Abizaid

2:54 pm: Atrioventricular Conduction System Changes During Transcatheter Aortic Valve Replacement (TAVR): Anatomic and Electrophysiologic Predictors of Heart Block in Prospective 400 Patient EPS/TAVR Study

Late-Breaking Science Presenter: Alfred Buxton

3:04 pm: Discussion

Lead Discussant: Tamim M. Nazif

3:12 pm: Outcomes of Patients With New Left Bundle Branch Block Following Transcatheter Aortic Valve Replacement: Insights From the NCDR STS/ACC TVT Registry

Late-Breaking Science Presenter: Nickpreet Singh

3:22 pm: Discussion

Lead Discussant: Amit N. Vora

More information: www.tct2023.crfconnect.com; or www.crf.org

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