May 5, 2015 — Biotronik announced that a unique physiologic sensor is now available in the latest family of cardiac resynchronization therapy defibrillator (CRT-D) devices. Closed Loop Stimulation (CLS) is the only cardiac sensor capable of appropriately adapting heart rate in response to physiologic demands independent of body movements or respiratory rate.
Chronotropic incompetence – the inability of the heart to increase its rate to keep up with increased activity or demand — is common in many heart failure patients. When programmed in a Biotronik device, CLS provides appropriate rate response, similar to patients with healthy sinus nodes.
Most other CRT-D devices use accelerometers, which are mechanisms that sense physical activity and require patients to be in motion before increasing their heart rate. Yet, patients need appropriate rate response regardless of whether they are actively moving or completely stationary. CLS more closely mimics the human nervous system, responding to patients’ metabolic changes. It can sense and respond to acute mental stress, adjusting the heart rate without relying on motion. CLS, available in Biotronik pacemakers since 2003, has been proven to be more responsive in activities of daily living than accelerometers.
“I've treated many patients with Biotronik’s pacemakers equipped with CLS and have had excellent results,” said Chad E. Bonhomme, M.D., cardiac electrophysiologist with Community Health Network in Indianapolis, Indiana. “CLS in ICDs offers a new and exciting option to more closely mimic normal physiology.
"In addition to rate adaptation, I look forward to seeing the potential benefits of increased exercise tolerance, improved heart variability and diminished orthostatic symptoms," continued Bonhomme.
The latest Biotronik Itrevia ICD and CRT-D series includes other advanced atrial therapies: morphology discrimination, Vp suppression, atrial capture control, improved ATP optimization and left ventricle (LV) pacing vectors. Combined, they create more therapeutic options to deliver effective therapy while reducing painful shocks. All devices include Biotronik Home Monitoring, a remote monitoring system with automatic daily transmission, which has been shown to reduce all-cause mortality by over 50 percent.
For more information: www.biotronik.com
May 22, 2023 
