Dixon GRE Technique Outperforms Clinical Standard for Unenhanced Coronary MRA

April 6, 2022 – According to ARRS’ American Journal of Roentgenology (AJR), the 3-T Dixon gradient-recalled echo (GRE) sequence performed higher than the current standard of 1.5-T SSFP for unenhanced coronary MRA, which could help expand clinical adoption of the procedure.

“For unenhanced coronary MRA, 3-T unenhanced Dixon GRE had better image quality and diagnostic performance than 1.5-T SSFP, particularly for distal and branch segments,” wrote lead researcher Hang Jin from China’s Fudan University and Shanghai Institute of Medical Imaging.

Jin and team’s prospective study included 44 patients (27 men, 17 women; mean age, 59 years) with intermediate-to-high risk of coronary artery disease who underwent both 1.5-T SSFP and 3-T Dixon GRE coronary MRA examinations before coronary angiography. Two radiologists independently assessed coronary arteries in random order for subjective image quality, number of visible segments, apparent contrast-to-noise ratio, and presence of significant stenoses.

Compared with 1.5-T SSFP, coronary MRA using 3-T unenhanced Dixon GRE demonstrated higher image quality (4.0±1.1 vs 3.0±1.2), higher percentage of visible coronary segments (96.7% vs 88.9%), as well as higher sensitivity (87.9% vs 77.3%) and specificity (83.3% vs 60.6%) for significant stenoses on a per-vessel basis, using coronary angiography as reference.

“The present results demonstrate the benefits of robust epicardial fat suppression using Dixon GRE in terms of improved apparent contrast-to-noise and improved visibility, with the latter difference observed particularly for distal and branch segments that course close to the myocardium,” the authors of this AJR article concluded.

Reference:

Unenhanced Whole-Heart Coronary MRA: Prospective Intraindividual Comparison of 1.5-T SSFP and 3-T Dixon Water-Fat Separation GRE Methods Using Coronary Angiography as Reference